Thyrotoxicosis with Palpable Nodule (Nucl) Fig. 25.7 Thyroid image in thyrotoxicosis in a patient with a palpable nodule. This image shows the uniform high uptake seen in Graves' disease with an area of reduced uptake (‘cold’ area) in the inferior pole of the right thyroid lobe. The incidence of malignancy in a solitary ‘cold’ nodule in a thyrotoxic gland is greater than that in a euthyroid gland. See also: • Graves' Disease See later: • ‘Cold’ Thyroid Nodule (Nucl) • ‘Warm’ Thyroid Nodule (Nucl)